A1c Sickle Cell Trait And Other Hemoglobin Variants

Dec 16 2017 Uncategorized

In people who have hemoglobin variants such as hbs (sickle cell trait), some a1c tests give falsely high or low readings that can lead to the over-treatment or under-treatment of diabetes. sickle cell trait and other hemoglobinopathies and diabetes: important information for physicians hanson se, schmidt rl, lin c-n, madsen rw, and. Hemoglobin a1c, also called a1c or glycated hemoglobin, is hemoglobin with glucose attached. individuals with some hemoglobin variants (e.g., sickle cell disease or thalassemia) in these cases, sickle cell trait and other hemoglobinopathies and diabetes: important information for physicians. national diabetes information clearinghouse. A1c assays are available that do not demonstrate a statistically significant difference in individuals with hemoglobin variants. other assays have statistically significant interference, but the difference is not clinically significant. association of sickle cell trait with hemoglobin a1c in african americans..

6.1 assess glycemic status (a1c or other glycemic measurement such as time in range or glucose management indicator) at least two times a year in patients who are meeting treatment goals (and who have stable glycemic control).e. 6.2 assess glycemic status at least quarterly and as needed in patients whose therapy has recently changed and/or who are not meeting glycemic goals.. Hemoglobin (haemoglobin bre) (from the greek word αἷμα, haîma ‘blood’ + latin globus ‘ball, sphere’ + -in) (/ ˌ h iː m ə ˈ ɡ l oʊ b ɪ n, ˈ h ɛ m oʊ ˌ-/), abbreviated hb or hgb, is the iron-containing oxygen-transport metalloprotein in red blood cells (erythrocytes) of almost all vertebrates (the exception being the fish family channichthyidae) as well as the tissues of some. Blakney g, higgins tn, holmes dj. comparison of hemoglobin a1c results by two different methods on patients with structural hemoglobin variants. clin biochem 1998;31:619-26. roberts wl, mccraw m, cook cb. effects of sickle cell trait and hemoglobin c on determinations of hba1c by immunoassay method. diabetes care 1998;21:983-6..

Some hemoglobin variants can affect some hba1c methods, but not all of them. for instance, certain variants can cause falsely high or low a1c test results depending on the method used. the a1c blood test, also called the hemoglobin a1c test, hba1c, or glycated hemoglobin test, reflects a person’s average blood glucose levels for the past 3. Description: hemoglobin electrophoresis blood test (quest) the hemoglobin electrophoresis test is used to detect and quantify both normal and abnormal forms of hemoglobin.hemoglobin is a protein in red blood cells which helps transport oxygen. measuring hemoglobin variants can help identify a number of inherited conditions which cause a person’s body to produce unusually low amounts or. The human alpha globin gene cluster located on chromosome 16 spans about 30 kb and includes seven loci: 5′- zeta – pseudozeta – mu – pseudoalpha-1 – alpha-2 – alpha-1 – theta – 3′. the alpha-2 (hba2) and alpha-1 (hba1) coding sequences are identical. these genes differ slightly over the 5′ untranslated regions and the introns, but they differ significantly over the 3′ untranslated regions..

Description: hemoglobin electrophoresis blood test (quest) the hemoglobin electrophoresis test is used to detect and quantify both normal and abnormal forms of hemoglobin.hemoglobin is a protein in red blood cells which helps transport oxygen. measuring hemoglobin variants can help identify a number of inherited conditions which cause a person’s body to produce unusually low amounts or. Hemoglobin (haemoglobin bre) (from the greek word αἷμα, haîma ‘blood’ + latin globus ‘ball, sphere’ + -in) (/ ˌ h iː m ə ˈ ɡ l oʊ b ɪ n, ˈ h ɛ m oʊ ˌ-/), abbreviated hb or hgb, is the iron-containing oxygen-transport metalloprotein in red blood cells (erythrocytes) of almost all vertebrates (the exception being the fish family channichthyidae) as well as the tissues of some. A1c assays are available that do not demonstrate a statistically significant difference in individuals with hemoglobin variants. other assays have statistically significant interference, but the difference is not clinically significant. association of sickle cell trait with hemoglobin a1c in african americans..